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Dual-Payload Conjugates: Addressing the CMC Challenges of a New Therapeutic Approach
Dual-payload conjugates—two mechanistically distinct payloads carried on a single targeting vehicle—represent the next technological frontier beyond conventional ADCs.
PMO Therapeutics: Technical Review and Manufacturing Platform Capabilities
This article offers a systematic overview of PMO drug technology covering underlying principles, manufacturing workflows, and therapeutic prospects.
Mechanistic Studies in Catalytic Process Development:
Supporting Manufacturing Processes and Revealing New Reaction Pathways
Through a case study on loading-dependent chemoselectivity in amide reductions, we demonstrate how first-principles chemical understanding provides the scientific foundation necessary for robust, end-to-end commercial manufacturing control strategies
FAQ: Applications of Different Synthetic Strategies for Peptide Process Development
What is the application value, cost characteristics and selection principles of pseudoproline dipeptides in peptide synthesis?
Antibody-Oligonucleotide Conjugates: From Conjugation Strategy to Purification and Analytical Control
Antibody-Oligo Conjugate (AOC), as an innovative targeted gene therapy biopharmaceutical, effectively integrates the targeting advantages of monoclonal antibodies and the gene regulatory functions of oligonucleotides, helping address key limitations in the inherent of traditional antibody drugs and nucleic acid drugs, and showing substantial clinical
FAQ: CMC Development Strategy for Oligonucleotides in AOCs
•How to reduce hydrolysis during SMCC conjugation?
•Can SMCC conjugate after hydrolytic ring-opening?
•How is OAR1 regulated during random SMCC conjugation?
•Which strategy is preferred for siRNA linker conjugation: pre-annealing or post-annealing conjugation?
Biocatalysis Enables the Efficient Synthesis and Commercial Application of Unnatural Amino Acids (UAAs)
Biocatalysis is a pivotal enabler for the sustainable synthesis of unnatural amino acids. By integrating novel enzyme discovery, multi-enzyme cascades and chemo-enzymatic routes, Porton has established practical capabilities to address industry challenges in substrate specificity and enzyme stability. Moving forward, Porton remains dedicated to bridging the gap between laboratory innovation and industrial-scale application, providing customers with reliable, scalable and atom-efficient solutions for UAA production.
Dry Particle Coating for the Enhancement of API Flowability and Bulk Density
The mechanism of the dry particle coating and a short description of four coating techniques including comil, LabRAM, a high shear mixer and a jet mill are provided.
Process Development and Quality Research Strategy for Dual-Payload Conjugated Drugs
What is the mainstream conjugation process for antibodies and siRNA?
