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Prep. Chromatography

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Prep. Chromatography

Prep. Chromatography

Porton has set up the technical team of prep-SFC and the R&D and production capacity of separation and purification in the Chongqing Liangjiang R&D Center. At present, the R&D center is equipped with analytic-grade SFC equipment and a number of chiral and achiral analysis columns that can quickly screen different prep-SFC separation conditions and realize the development and optimization of SFC separation methods. Preparation-grade SFC equipment for scale-up production has a capacity of approximately 1-5 kg per month (depending on the separation method), with dynamic compression columns and spring columns that can be filled with a variety of fillers as required by the project and the separation method.

Capability

Technology Scope GMP Scale
Prep-SFC
  • Method Development & Optimization
  • Chiral Separation Or Purification Production
  • Impurity Preparation
Non-GMP & GMP Currently 1~10 kg
Product/month
Prep-HPLC
  • Method Development & Optimization
  • Separation Or Purification Production
  • Impurity Preparation
  • High Potency Compound Applicable
Non-GMP & GMP Currently 1~20 kg
Product/month
Nano-/Ultrafiltration
  • Process Development & Optimization
  • Concentration Production
Non-GMP & GMP Currently 10~100 L
Solution/hr
Lyophilization
  • Process Development & Optimization
  • Lyophilization Production
  • High Potency Compound Applicable
Non-GMP & GMP Currently ~10 L
Solution/batch
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