Optimization of Synthetic Process and Metal-Chelation Impurity Control Strategy for Complex Peptide-based RDCs Download

Radionuclide-Drug Conjugates (RDCs) are core carriers for the integrated diagnosis and treatment of tumors, enabling simultaneous precise diagnosis and tumor killing. Among them, peptide-based RDCs have become an important direction for cancer treatment due to their high matching degree between half-life and radionuclides, excellent targeting, and good safety. To date, more than 400 RDC-related clinical trials have been registered worldwide. Despite their broad application prospects, R&D a