Case Studies & WhitepapersJun 04, 2025
Flow Chemistry: A New Technology to Enhance the Traditional Batch Process in the Delivery Requirement
Continuous reaction can effectively solve the problem of "amplification effect" in batch processes from research and development to pilot testing, and then again to commercial production. Porton’s continuous reaction capabilities include low-temperature lithiation reaction, ozone oxidation reaction, nitrification reaction, high-temperature reaction, and organic azide reaction, etc., which can achieve process development and technology transfer from research and development to production application.
Small MoleculesApr 27, 2025
Comprehensive Analytical R&D and QC Expertise in Pharmaceutical Development
This white paper details our extensive capabilities in Analytical Research and Development (R&D) and Quality Control (QC) for pharmaceutical drug development. It highlights our expertise in method development, structure elucidation, and method troubling. Our goal is to ensure the highest standards of quality and efficiency in drug development and manufacturing.
Biologics and ConjugatesApr 23, 2025
Challenges and Advances in CMC Process Development of BsADCs
Antibody drug conjugates (ADCs) have seen significant breakthroughs and reached numerous milestones since 2000 when the first ADC was approved by the FDA and have shown great promise for the treatment of cancer. First generation ADCs were designed to use the affinity of an antibody towards a specific cellular target to bring the cytotoxic payload to the tumor, for example. However, some level of off-target toxicity was often seen with many ADCs because other cellular interactions could occur prior to the payload physically reaching its intended target or the payload could cleave off. These events could lead to unintended death of non-cancerous cells.
Case Studies & WhitepapersMar 24, 2025
Preformulation Strategy- Inception to Completion
Drug discovery is an exceedingly complex process. Discovering a new chemical entity is in itself a huge accomplishment, which is often possible only after almost two decades of hard experimental work as well as advanced simulation efforts. Therefore, the next stage of the process, determination of toxicity becomes even more crucial as most new chemical entities (NCE) are disqualified if the NCE shows a potential toxic effect, despite any possible therapeutic effect.
Small MoleculesMar 13, 2025
Facilitating PROTAC Drugs Development with Innovative Processes
The PROTAC technology, through an innovative mechanism of "degradation rather than inhibition," provides a new pathway for targeting traditionally undruggable proteins and addressing resistance issues.
Biologics and ConjugatesFeb 10, 2025
Efficacy and Safety - Guidelines for Clinical In-use Stability Studies of ADCs
Antibody-drug conjugates (ADCs) consist of three parts: antibody, linker, and payload. This special combination enables ADCs to selectively target tumor cells and release cytotoxic drugs, but they face many stability challenges during manufacture, storage, and clinical use. In this paper, the drug product development team at Porton (hereinafter referred to as "we") discusses the necessary clinical in-use stability studies for ADCs.
Case Studies & WhitepapersJan 06, 2025
Molecular Modeling and Data Science for De-risking and Cost- saving of Pharmaceutical Development
Molecular Modeling and Data Science for De-risking and Cost- saving of Pharmaceutical Development
Small MoleculesJan 06, 2025
Continuous Improvement of Project Life Cycle Management, Benefiting Customers by Reducing Total Cost
Continuous Improvement of Project Life Cycle Management, Benefiting Customers by Reducing Total Cost
Case Studies & WhitepapersJan 03, 2025
Agile and Fast：Enabling Rapid Market Launch of Innovative Drugs from Preclinical to Commercialization in 18 Months
Enabling Rapid Market Launch of Innovative Drugs from Preclinical to Commercialization in 18 Months
