Globally Leading Biocatalysis Platform
"One-stop" Biocatalysis Solutions, from R&D to Commercial Manufacturing
2000+
Enzymes
80+
Reaction Types
50+
Application Projects/Year
Biocatalysis
Traditional chemical methods for pharmaceutical synthesis and manufacturing are frequently hindered by low selectivity, process complexity, and sustainability concerns. To overcome these challenges, Porton Pharma Solutions has built a world-class, full-capability biocatalysis platform, delivering one-stop, end-to-end biocatalytic solutions and CDMO services.
R&D: A Fully Functional R&D System
Powerful Enzyme R&D Capabilities, Deeply Integrated with Chemical Synthesis
Enzyme Development
- Robust, Free-to-operate, Ready-to-use, Continuously Expanding Enzyme Library
- 2,000+ Enzymes Covering 80+ Reaction Types
- Automation-enabled HTS Screening
- AI-assisted Enzyme Design and Development
- Full Enzyme Formulations: Solution, Powder, and Immobilized Enzyme
- Comprehensive Enzyme Quality System
- Focus on Key Chiral Motifs, Including Chiral Amines, Alcohols, Acids, Esters, Amides, and UAAs
Enzyme Application
- Deep Integration with Chemical Synthesis for Efficient Route Design
- Chemical Step Replacement and Overall Route Redesign
- Multi-technology Integration: Multi-enzyme cascade, Chemoenzymatic, Flow Enzymatic, and Enzyme-Crystallization Coupling
- QbD- and DoE-guided Enzymatic Process Development and Optimization
- Quality-driven Residual Protein Testing
- Cost-driven Continuous Process Optimization and Lifecycle Management
- 50+ Biocatalysis Projects per Year
Manufacturing: High-capacity Production Capabilities
Enzyme Fermentation and Enzyme-catalyzed Chemical Production, with Metric-ton Delivery Capacity
Enzyme Fermentation
- Dedicated Facility with Gravity-flow Design
- Flexible Capacity: 1.5 L to 10,000 L; Monthly Output up to 12 Metric Tons
- Highly Automated Fermentation and Workup Systems
- Standardized Processes for Strain Preparation, High-density Fermentation, and Formulation
- Full-chain Quality Management: Raw Materials, In-process, and Finished Products
- Integrated R&D, Manufacturing, QC, and Supply Chain Collaboration
Enzyme-Catalyzed Chemical Production
- 100+ Projects Delivered, Including Metric-ton Scale Production
- No Dedicated Equipment Required, Single-batch Yield up to 500+ kg
- Extensive and Proven Experience in Handling Both Enzyme Powders and Solutions
- Precise, Controllable Material Charging Strategies
- Real-time pH Monitoring and Control
- Capable of Both Non-GMP and GMP Production
Specialized Platforms: Innovation Engine
Unnatural Amino Acid (UAA) Synthesis and Enzyme Immobilization Platforms—Driving Greener, More Efficient Manufacturing
UAA Synthesis Platform
- Multiple Chem-enzymatic Routes for UAA Synthesis
- Platform-based Development—Each Route Applicable to Multiple Products
- One-pot Multi-enzyme Cascade—Industrially Proven
- Applicable to Both D- and L-UAAs
- 10+ Projects Delivered, Including Metric-ton Scale Production
Enzyme Immobilization Platform
- Standardized Workflow: Carrier Screening, Process Development, Application, and Production
- Multiple Enzymes Immobilized and Industrialized
- Enzyme Reuse Exceeding 50 Cycles, Reducing Enzyme Consumption by over 90%
- Customized R&D and Production Equipment
- 5+ Projects Delivered, Including 100-ton Scale Production
Case Studies
Biocatalysis Enables The Efficient Synthesis and Commercial Application of Unnatural Amino Acids (UAAs)
The Perfect Integration of Immobilized Enzymes and Flow Chemistry: A Powerful Booster for the Commercialization of Biocatalysis Technology
Biocatalysis: A Powerful and Possible Greener Tool for Chemists in the Pharmaceutical Industry
